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Table 1 Global regulators and their regulated operons and functions in the regulatory network of E. coli.

From: Hierarchical structure and modules in the Escherichia coli transcriptional regulatory network revealed by a new top-down approach

Global regulator

directly regulated Operons

Total regulated operons

Modules regulated

Function

IHF

21

39

15

integration host factor

CspA

2

24

5

Cold shock protein

CRP

72

112

21

cAMP receptor protein

FNR

22

38

16

anaerobic regulator, regulatory gene for nitrite and nitrate reductases, fumarate reductase

HNS

7

22

5

DNA-binding global regulator; involved in chromosome organization; preferentially binds bent DNA

OmpR

6

20

3

Response regulator for osmoregulation; regulates production of membrane proteins

RpoN

12

17

4

RNA polymerase sigma 54 subunit

RpoS

14

24

8

stationary phase sigma factor

ArcA

20

21

6

Response regulator protein represses aerobic genes under anaerobic growth conditions and activates some anaerobic genes

NarL

13

15

5

Two-component regulator protein for nitrate/nitrite response