Analysis of residuals of PLGEM fitted on three different real-life data sets. (A) PLGEM is fitted on the 16iDC data set (MG-U74Av2) following the method described in the text, setting p = 10 and q = 0.5. (B) Model residuals are plotted as a function of the rank of the mean absolute expression level. (C) Distribution of pooled residuals. (D) The quantiles of the distribution of pooled residuals are plotted against the quantiles of a standard normal distribution. The same procedure is applied to the Leigh syndrome data set (HG-U133A, panels E-H) and to the Muscle biopsies data set (HG-U95Av2, panels I-L).