Skip to main content

Table 2 Example of genes with significant interaction effects

From: Analysis of oligonucleotide array experiments with repeated measures using mixed models

Gene LOC91614 Cathepsin H
   OB CER OB CER
Con 7.02 6.61 6.58 6.78 7.09 6.83 10.53 10.63 10.49 9.46 9.71 9.42
   6.74 ± 0.25 6.90 ± 0.17 10.55 ± 0.07 9.53 ± 0.16
AD 7.58 7.59 8.21 5.30 5.03 5.58 12.30 12.41 12.37 9.54 9.82 9.79
   7.80 ± 0.36 5.30 ± 0.28 12.36 ± 0.06 9.72 ± 0.15
Overall P 0.00058 2.12e-06
Interaction P 0.00036 5.86e-06
ConOB vs ADOB Re + +
  fold 2.08 3.51
  dir I I
ConCER vs ADCER Re + +
  fold 0.33 1.14
  dir D N
ConOB vs ConCER Re - +
  fold 0.90 2.03
  dir N I
ADOB vs ADCER Re + +
  fold 5.66 6.23
  dir I I
  1. ConOB_ADOB: control vs AD for OB; ConCER_ADCER: control vs AD for CER; ConOB_ConCER: OB vs CER for control subjects; ADOB_ADCER: OB vs CER for AD patients. Overall P: the P value of the generalized F test. Interaction P: the P value of the interaction term. Re: the results of the protected Fisher's LSD procedure, where "+" indicates a significant difference and "-" implies a non significant difference ; dir: the direction of alteration in gene expression levels; D for decrease, I for increase and N for no change in AD when comparing control vs AD, or in OB when comparing CER vs OB; fold: fold change of each pairwise comparison calculated from the inverse transformed log2 based data. The fold change of LOC91614 gene expression between AD and control in OB was calculated as: 2(7.58+7.59+8.21)/3/2(7.02+6.61+6.58)/3 = 2.08. The fold changes in other situations were calculated in a similar way. Similar notations were also used in Table 3. See also Figure 1.