Gene | LOC91614 | Cathepsin H |
|---|
| Â | Â | OB | CER | OB | CER |
Con | 7.02 | 6.61 | 6.58 | 6.78 | 7.09 | 6.83 | 10.53 | 10.63 | 10.49 | 9.46 | 9.71 | 9.42 |
|  |  | 6.74 ± 0.25 | 6.90 ± 0.17 | 10.55 ± 0.07 | 9.53 ± 0.16 |
AD | 7.58 | 7.59 | 8.21 | 5.30 | 5.03 | 5.58 | 12.30 | 12.41 | 12.37 | 9.54 | 9.82 | 9.79 |
|  |  | 7.80 ± 0.36 | 5.30 ± 0.28 | 12.36 ± 0.06 | 9.72 ± 0.15 |
Overall P | 0.00058 | 2.12e-06 |
Interaction P | 0.00036 | 5.86e-06 |
ConOB vs ADOB | Re | + | + |
| Â | fold | 2.08 | 3.51 |
| Â | dir |
I
|
I
|
ConCER vs ADCER | Re | + | + |
| Â | fold | 0.33 | 1.14 |
| Â | dir |
D
| N |
ConOB vs ConCER | Re | - | + |
| Â | fold | 0.90 | 2.03 |
| Â | dir | N |
I
|
ADOB vs ADCER | Re | + | + |
| Â | fold | 5.66 | 6.23 |
| Â | dir |
I
|
I
|
- ConOB_ADOB: control vs AD for OB; ConCER_ADCER: control vs AD for CER; ConOB_ConCER: OB vs CER for control subjects; ADOB_ADCER: OB vs CER for AD patients. Overall P: the P value of the generalized F test. Interaction P: the P value of the interaction term. Re: the results of the protected Fisher's LSD procedure, where "+" indicates a significant difference and "-" implies a non significant difference ; dir: the direction of alteration in gene expression levels; D for decrease, I for increase and N for no change in AD when comparing control vs AD, or in OB when comparing CER vs OB; fold: fold change of each pairwise comparison calculated from the inverse transformed log2 based data. The fold change of LOC91614 gene expression between AD and control in OB was calculated as: 2(7.58+7.59+8.21)/3/2(7.02+6.61+6.58)/3 = 2.08. The fold changes in other situations were calculated in a similar way. Similar notations were also used in Table 3. See also Figure 1.
