The architecture of the model used in this work. The 3 "sub-models" corresponding to the 3 labels are shown separately. In the transmembrane sub-model different colors correspond to the tied states. Black circles correspond to the aromatic belt, gray to exterior of the strand's core, and white to the interior side. In the inner and outer loop sub-models, the states forming the ladder are tied together respectively, whereas the N-terminal tail is tied with the C-terminal and the globular outer loop state is not tied with another state. The allowed transitions are shown with arrows.