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Table 1 50 best clusters from average method with MIPS classes

From: Selection of informative clusters from hierarchical cluster tree with gene classes

Ordinal number

Most enriched MIPS gene class

Log-p-value

Bonf. corr. log(p)

Observed

Clust. size

Class size

1

cytoplasmic ribosomes

102.5676

99.7780

78

159

108

2

respiration chain complexes

61.0379

58.2483

28

41

31

3

mitochondrion

57.3513

54.5617

75

142

305

4

AA metabolism

55.4905

52.7009

75

259

171

5

AA biosynthesis

55.4849

52.6953

59

244

98

6

mitochondrial ribosomes

46.2851

43.4955

32

101

46

7

rRNA transcription

33.5036

30.7140

46

274

99

8

cytoplasmic ribosomes

25.8871

23.0975

15

15

108

9

nucleosomal protein complex

25.2346

22.4450

8

8

8

10

26S proteasome

23.1373

20.3477

12

21

28

11

glycolysis and gluconeogenesis

21.1692

18.3796

10

13

28

12

cytoplasmic ribosome large subunit

20.5629

17.7734

11

12

63

13

purine ribonucleotide metabolism

20.4238

17.6342

9

9

33

14

mitochondrion

19.3933

16.6038

19

24

305

15

pher. resp., mating-type determination, sex-specific proteins

18.8355

16.0460

13

15

140

16

fungal cell differentiation

18.066

15.2764

17

20

318

17

phosphate metabolism

17.3187

14.5291

9

15

29

18

lipid, FA. and isoprenoid biosynthesis

16.8961

14.1065

14

32

88

19

cytoplasmic ribosome large subunit

16.6398

13.8502

9

10

63

20

cell cycle and DNA processing

16.6338

13.8442

51

153

493

21

26S proteasome

15.6397

12.8501

8

13

28

22

aminoacyl-tRNA-synthetases

14.2599

11.4660

7

10

28

23

nucleus

13.8439

11.0544

119

475

687

24

mitochondrial ribosomes

13.1286

10.3389

7

9

46

25

carbon compound and CH. transporters

12.373

9.5834

15

235

31

26

pher. resp.

12.1225

9.3329

6

8

32

27

carbon compound and CH. utilization

12.1195

9.3299

24

114

192

28

rRNA processing

12.0528

9.2632

12

59

60

29

metabolism of energy reserves

11.7646

8.9750

11

98

30

30

nitrogen and sulfur metabolism

11.5355

8.7459

6

7

49

31

unclassified proteins

11.3345

8.5449

34

79

656

32

alpha, alpha-trehalose-phosphate synthase

11.2183

8.4287

4

10

4

33

carbon compound, CH. transport

11.0861

8.2965

15

300

30

34

splicing

11.001

8.2114

25

378

74

35

heavy metal ion transporters

10.9979

8.2083

7

34

19

36

translation

10.8811

8.0915

6

8

50

37

cation transporters

10.5607

7.7711

11

75

48

38

F0/F1 ATP synthase (complex V)

10.1474

7.3579

4

5

12

39

lipid, FA. and isoprenoid metabolism

9.8666

7.0770

7

8

159

40

cytoplasmic ribosome large subunit

9.7246

6.9350

5

5

63

41

subcellular localization

9.51

6.7204

265

562

1885

42

homeostasis of metal ions

9.5024

6.7128

10

67

50

43

AA degradation (catabolism)

8.9569

6.1673

5

12

25

44

glycine decarboxylase

8.8106

6.0210

3

5

4

45

ribonucleoside-diphosphate reductase

8.8106

6.0210

3

5

4

46

ER

8.8061

6.0165

72

1613

131

47

mitochondrial inner membrane

8.6293

5.8397

5

5

103

48

cytoskeleton

8.3735

5.5839

6

11

81

49

ER lumen

7.9589

5.1694

4

18

9

50

energy

7.3865

4.5969

5

5

181

  1. The table shows the ordinal number of the each obtained cluster shown in the figure 2, functional class that was most enriched in the cluster, and the log10-p-value for the most enriched class with and without Bonferroni-correction. Table shows also number of class members in the cluster (observed), size of the cluster (clust. size), and size of the functional class. The five most enriched functional classes can be found from table 4 [additional file 1]. Notice clusters that include only or almost only functional class members (8, 9, 12, 13, 15, 19 etc.) and the clusters that include the whole or almost the whole functional class (2, 9, 32 etc.). An especially good example is cluster 9 as it includes all the histone complex members and only histone complex members. Also it is worthwhile to notice the extremely small obtained p-values (for example, log-p-value 12 would refer to p-value 10-12). Abbreviations are: AA, amino acid; metab, metabolism; pher. resp. pheromone response; CH, carbohydrate; FA, fatty-acid. More details of these results are shown in table 4 [Additional file: 1].