Figure 3

A: Decision tree predictions compared with four high-throughput datasets and their simple combinations. B and C: Decision tree predictions compared with two APMS studies: TAP (B) and HMS-PCI (C), respectively. Only protein pairs covered by each respective study (using the "spoke" model [30]) were considered. Black solid line: decision tree predictions using all attributes; blue solid line: decision tree predictions using only high-throughput interaction datasets; grey solid line: decision tree predictions using all attributes together with the categories "same function" and "same protein class"; black dotted line: expected performance of random guesses.