Alternative splicing in the cyclin-dependent kinase 2 (cdk2). a. Amino acid sequence of the protein. Spliced regions are colored red. The first (N-terminal) region was identified based on the homology with the deletion type cdk2 variant in human breast cancer (protein id BAA32794.1). The second (C-terminal) region was identified based on the homology with the human cDNA sequence associated with leiomyosarcoma (GenBank accession number BQ225275). b. Graphical representation of spliced regions (red) and sequence spans involved in protein-protein interactions (blue). The full amino acid sequence is shown as black bar. c. Ribbon representation of the three-dimensional structure of cdk1 (PDB code 1fin, chain a). Regions involved in protein-protein interactions are shown in blue colour, spliced regions are red. Violet colour indicates regions where PPI and AS regions overlap.