Detection of intensity dependence of measured differences in other normalization methods, using the same data sets shown in Fig. 5. The upper part of the panels are examples of rank vs. log-ratio plots for data comparison , and the lower part of the panels are histograms at the indicated ranges of ranks. a. Normalized by a globalization. b. Normalized by LOWESS method . c. Normalized by a variance stabilization method . d. The same method as seen in panel c but using the opposite direction of adjustment; the control data were adjusted to the 24 hr data. Since the method transforms only one of the data sets, the resulting normalized data can be different; in this case, the same result will form a mirror image of panel c. Green and blue lines show the moving average and moving standard deviation, respectively; the window of the calculation was 200.