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Table 1 Sensitivity, selectivity, specificity and correlation of PROSITE test cases and the corresponding extended patterns.

From: A structural study for the optimisation of functional motifs encoded in protein sequences

ACa typea Snb Slb Spb Cb
AA_TRNA_LIGASE_II_1 prosite 0.648 0.802 0.9994 0.720
  extended 1 0.648 0.908 0.9997 0.767
  extended 2 0.719 0.813 0.9994 0.764
AA_TRNA_LIGASE_II_2 prosite 0.531 0.464 0.9977 0.494
  extended 1 0.528 0.617 0.9988 0.569
  extended 2 0.622 0.528 0.9979 0.572
ASP_PROTEASE prosite 0.974 0.836 0.9996 0.902
  extended 1 0.974 0.921 0.9998 0.947
  extended 2 0.984 0.900 0.9998 0.941
EGF_1 prosite 0.679 0.792 0.9993 0.733
  extended 1 0.679 0.936 0.9998 0.796
  extended 2 0.750 0.864 0.9995 0.805
LIPOCALIN prosite 0.667 0.461 0.9992 0.554
  extended 1 0.667 0.864 0.9999 0.759
  extended 2 0.771 0.871 0.9999 0.820
RRM_RNP_1 prosite 0.582 0.537 0.9985 0.558
  extended 1 0.582 0.719 0.9993 0.646
  extended 2 0.629 0.614 0.9988 0.620
THIOL_PROTEASE_HIS prosite 0.785 0.459 0.9986 0.596
  extended 1 0.785 1.000 1.0000 0.886
  1. a Pattern accession number (AC) in the PROSITE database and the type of pattern (type): PROSITE, extended 1 or extended 2b Sensitivity Sn (defined as Sn = TP/(TP + FN)), selectivity Sl (Sl = TP/(TP + FP)), specificity Sp (Sp = TN/(TN + FP))and correlation C (C = [TP × TN - FP × FN]/ [(TP + FP) × (FP + TN) × (TN + FN) × (FN + TP)]1/2) of the patterns on the SWISS-PROT release 40.8. TN is the number of true negatives, which is calculated as the total number of sequences on the SWISS-PROT release 40.8 (= 101659) less the sum of true positive, false negative and partial sequences.