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Table 1 Muscle and RMS gene density in the human genome.

From: Detection of chromosomal regions showing differential gene expression in human skeletal muscle and in alveolar rhabdomyosarcoma

Chr.

Chromosomal regions

Diff. expr. in RMS

Chr.

Chromosomal regions

Diff. expr. in RMS

 

Start(Mb)

End(Mb)

Cyt. band

  

Start(Mb)

End(Mb)

Cyt. band

 

1

14.09

14.75

p36.21*

+

     
 

50.16

50.79

p32.3

+

     
 

63.86

64.11

p31.3

+

13

59.57

59.69

q21.2

+

 

91.99

92.09

p22.1

-

 

94.91

95.14

q32.1

-

 

96.84

97.50

p21.3

-

     
 

173.14

173.59

q25.2

-

     

2

29.21

30.22

p23.2 – p23.1*

+

     
 

50.05

51.22

p16.3

-

     
 

79.57

81.03

p12

-

     
 

99.66

100.17

q11.2

-

14

65.07

65.58

q23.3

-

 

137.73

138.53

q22.1

+

 

71.51

71.57

q24.2

-

 

143.91

144.65

q22.2-q22.3

+

     
 

205.48

206.28

q33.3

-

     
 

212.32

213.26

q34

-

     

3

2.03

3.16

p26.3-p26.2

+

     
 

29.28

29.78

p24.1

-

     
 

37.17

37.19

p22.3

-

     
 

37.24

37.61

p22.3

-

     
 

53.92

55.06

p21.1-p14.3*

+

     
 

61.51

62.03

p14.2

-

15

22.97

23.04

q11.2

-

 

76.79

77.61

p12.3*

+

     
 

101.86

102.32

q12.2-q12.3

-

     
 

116.71

117.55

q13.31

+

     
 

160.38

160.91

q25.33

-

     
 

176.08

176.82

q26.31

-

     

4

53.52

54.15

q12

+

     
 

87.50

88.06

q21.3

-

     
 

114.54

114.90

q25-q26

-

16

82.50

83.51

q23.3

-

 

151.75

152.30

q31.23-q31.3

-

 

88.74

88.88

q24.3*

+

 

162.88

163.45

q32.2

-

     
 

168.14

168.84

q32.3

+

     

5

19.37

20.08

p14.3

+

     
 

89.80

90.59

q14.3

+

17

44.45

44.72

q21.31

-

 

92.87

93.54

q15

+

 

45.08

45.13

q21.31

-

 

168.12

168.58

q34-q35.1

-

     

6

1.51

2.39

p25.3-p25.2

+

     
 

20.70

21.19

p22.3

-

     
 

37.94

38.43

p21.2

-

     
 

44.67

45.37

21.1*

+

18

7.66

8.29

p11.23

-

 

69.40

70.07

q12-q13

-

 

49.86

50.84

q21.1-q21.2

-

 

128.69

129.74

q22.33

-

     
 

152.69

153.01

q25.2

+

     

7

36.54

37.32

p14.2-p14.1

+

     
 

68.36

69.76

q11.22*

+

     
 

100.90

10.1

q22.1*

+

19

38.48

38.54

q13.11*

+

 

109.95

110.64

q31.1

-

     
 

132.56

133.21

q33

-

     

8

98.97

99.41

q22.2

-

20

8.18

8.71

p12.3

-

9

8.41

8.90

p24.1

-

     
 

109.93

109.99

q32*

+

21

16.32

16.61

q21.1

-

 

112.29

113.53

q32-q33.1*

+

     
 

121.63

122.47

q33.3*

+

     

10

0.50

0.75

p15.3*

+

     
 

52.83

53.84

q21.1

-

     
 

75.66

76.54

q22.2*

+

22

31.87

32.74

q12.3*

+

 

78.64

79.18

q22.3

-

     
 

94.41

94.48

q23.33

-

     
 

108.33

109.16

q25.1

+

     

11

10.20

10.28

p15.4

-

     
 

10.34

10.34

p15.4

-

X

8.74

9.47

p22.31-p22.22*

+

 

20.60

21.90

q22.3

+

 

83.54

84.02

q21.2

-

 

83.50

84.83

q14.1

-

 

94.08

94.79

q21.33

-

12

26.85

26.92

p11.23

-

Y

-

-

-

 
  1. Local density of genes expressed in skeletal muscle and in RMS was calculated on the basis of 304,691 sliding windows, 1 Mb-wide and with 10 Kb overlap. Chromosomal regions in which the absolute difference between RMS and skeletal muscle gene density was over 0.6 were selected. Thirty-three chromosomal regions harbouring mostly genes expressed in RMS and 48 chromosomal segments, possibly related to function of differentiated skeletal muscle but silent in RMS are reported. Regions including chromosomal segments in which absolute difference between ARMS and skeletal muscle gene density exceeded 1.0 are in bold, whereas asterisks indicate regions in which overexpression of tumour genes has been reported for different tissues by Zhou and colleagues [10].