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Table 1 Selected potential cleavage sites in human proteins from the Swiss-Prot database examined in this work. Columns represent Swiss-Prot identifier, predicted cleavage site position of P1 in the target protein, cleavage site score, and cellular localisation of target protein (Cyt – cytoplasmic, Nuc – nuclear, Mem – membrane associated). The last column lists the cleavage site in the sequence – cleavage is predicted between the central glutamine residue (Q) and the following amino acid residue. Sorted by prediction score.

From: Coronavirus 3CLproproteinase cleavage sites: Possible relevance to SARS virus pathology

Swiss-Prot ID Loc Position Score Sequence
AT6B_HUMAN Nuc 358 0.916 EARLQ AVLAD
INI2_HUMAN Mem 97 0.890 VATLQ SLGAG
PO21_HUMAN Nuc 62 0.874 GTSLQ AAAQS
IRA1_HUMAN Cyt 457 0.859 QSTLQ AGLAA
CFTR_HUMAN Mem 762 0.842 GPTLQ ARRRQ
SCAD_HUMAN Mem 22 0.828 GSHLQ AAAQT
P532_HUMAN Nuc 308 0.782 ASVPQ STGNA
RPC1_HUMAN Cyt 195 0.765 SNFLQ SFETA
P531_HUMAN Nuc 196 0.738 KEQLQ SVTTN
T2D1_HUMAN Nuc 741 0.730 GQLLQ AFENN
P532_HUMAN Nuc 197 0.725 KAALQ QKENL
RPA1_HUMAN Cyt 329 0.704 TVNLQ AVMKD
CFTR_HUMAN Mem 958 0.693 HSVLQ APMST
MAE1_HUMAN Cyt 64 0.661 KVKFQ AKLEH
MAE3_HUMAN Cyt 64 0.661 KVKFQ AKLEH
P531_HUMAN Nuc 410 0.660 QKKLQ SGEPV
CFTR_HUMAN Mem 890 0.654 NTPLQ DKGNS
P532_HUMAN Nuc 722 0.624 SPNLQ NNPEE
T2DT_HUMAN Nuc 133 0.619 PSSVQ SVAVP
T2D3_HUMAN Nuc 610 0.570 SSGKQ STETA
MAP4_HUMAN Cyt 1005 0.519 YSHIQ SKCGS
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