Figure 4

Unfiltered Predicted complexes. (a) Clusters of predicted complexes for each of the four families. Receptor models are shown as α-carbon traces in red. Each gray point indicates the center position of a GRAMM hit. (b) Predicted complexes vs. the known complex for APAF1/CASP9. The receptor (APAF1) of the predicted complexes is shown as α-carbon trace in gray; the ligand center points are shown as gray points with direction vectors. The known complex is shown in blue. Note that the known (blue) and predicted (gray) APAF1's have been aligned, and that the known CASP9 center is not within the dense regions of predicted centers.