Figure 2
From: Target SNP selection in complex disease association studies
Allele frequencies of 1,633 SNPs in the Caucasian population (which is a random SNP subset of the 19,495 annotated SNPs on chromosome 6p21) by type of functional change. SNP allele frequencies were on average 4% lower in the two bottom tertiles (P = 0.004) of the frequency distribution in those SNPs that insert a new transcription factor binding site (red line) compared to SNPs that destroyed a binding site or were not found in any motif (black line).