Table 2 Prediction results for 30 different GPCR subtypes with known coupling properties extracted from the gpDB database [18] that are not included in the training set [37]. The annotation of GPCR coupling properties in gpDB is based on data from the scientific literature. According to the gpDB classification scheme, Ggust and Gt G-proteins belong to the Gi/o subfamily and Golf to the Gs subfamily. The GPCR sequences were extracted from gpDB and parsed into our prediction server http://bioinformatics.biol.uoa.gr/PRED-COUPLE.
GPCR Subtype | Uniprot AC | observed | predicted |
|---|---|---|---|
5-OXO-ETE receptor TG1019 | Q8TDS5 | Gi/o | Gq/11 |
Allatostatin receptor | Q9W4R0 | Gi/o | Gi/o Gq/11 |
Apelin receptor | P35414 | Gi/o | Gi/o |
Gonadotropin releasing hormone I receptor | Q92644 | Gq/11 | Gi/o |
Gonadotropin releasing hormone II receptor | Q8TCX8 | Gq/11 | Gq/11 |
Gustatory receptor 43 | Q9JHE2 | Ggust | Gi/o |
Gustatory receptor GUST27 | P34987 | Gi/o | Gi/o |
Neuromedin U1 receptor | Q9JIB2 | Gq/11 | Gq/11 Gi/o |
Neuromedin U2 receptor | Q9NRA6 | Gq/11 | Gq/11 Gi/o |
Nicotinic Acid receptor | Q8TDS4 | Gi/o | Gi/o |
Olfactory receptor 10A7 | Q96R19 | Golf | Gs |
Blue opsin | Q13877 | Gt | Gi/o |
Orexin 1 receptor | O43613 | Gq/11 | Gi/o Gq/11 |
Orexin 2 receptor | O43614 | Gq/11 | Gi/o Gq/11 |
Platelet activating factor receptor | P25105 | Gi/o Gq/11 | Gi/o |
Prolactin-releasing peptide receptor | O75194 | Gq/11 | Gi/o |
Trace amine receptor TAR | Q9P1P4 | Gs | Gs |
Trace amine receptor TAR-1 | Q96RJ0 | Gs | Gq/11 Gs Gi/o |
Trace amine receptor TAR-2 | Q923Y7 | Gs | Gs Gi/o |
Trace amine receptor TAR-3 | Q96RI9 | Gs | Gi/o Gs |
Urotensin II receptor | Q9UKP6 | Gq/11 | Gi/o |
Gastric inhibitory peptide receptor | Q9UPI1 | Gs | Gs |
Glucagon Receptor | P47871 | Gs | Gs |
Glucagon like peptide receptor 2 | O95838 | Gs | Gs |
Ghrelin receptor | Q96RJ7 | Gq/11 | Gq/11 |
Parathyroid hormone receptor 1 | P49190 | Gs | Gs |
Parathyroid hormone receptor 2 | Q03431 | Gs | Gs |
Secretin receptor | Q13213 | Gs | Gs |
Calcium-sensing receptor | P41180 | Gi/o Gq/11 | Gi/o |
Taste receptor TASTE_TB334 | Q62942 | Ggust | Gi/o |