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Table 2 The gene product functions described herein are listed with their associated GO molecular functions and parameters. These gene product functions are mapped to corresponding Gene Ontology molecular functions. These GO functions are integrated into an object-oriented model by amending them with input and output parameters, thereby creating object functions.

From: Integration of the Gene Ontology into an object-oriented architecture

Gene Product

Gene Product Function

Corresponding GO Term and GO ID

Input

Output

Figure Location

TGF-beta

Dimerize

protein homodimerization activity (GO:0042803)

2X TGF-beta

Dimerized TGFβ

Fig.4

 

bind TGF-beta receptor

TGF-beta receptor binding (GO:0005160)

TGFβ homodimer

TGFβR homodimer

TGFβ-TGFβR complex

Fig.4

TβRII

Dimerize

protein homodimerization activity (GO:0042803)

2X TβRII

Dimerized RII

Fig.4

 

TGF-beta binding

TGF-beta binding (GO:0060431)

TβRII homodimer

TGFβ homodimer

TGFβ-TβRII heterotetramer

Fig.2, 4

 

Heterotetramerize

protein heterodimerization activity (GO:0046982)

TβRI homodimer

TβRII homodimer

TβRI-TβRII heterotetramer

Fig.2, 4

 

phosphorylate RI

transferase activity (GO:0016740)

ATP

TβRI homodimer

phosphorylated TβRI

Fig.2, 4

TβRI

Dimerize

protein homodimerization activity (GO:0042803)

2X TβRI

Dimerized RI

Fig.4

 

Heterotetramerize

protein heterodimerization activity (GO:0046982)

TβRI homodimer

TβRII homodimer

TβRI-TβRII heterodimer

Fig.2, 4

 

TβRI activation

phosphate binding (GO:0042301)

ATP

TβRI

phosphorylated TβRI

Fig.4

 

bind SMAD2

Smad binding (GO:0046332)

SMAD2

TGFβ-TβRII-TβRI-SMAD2 complex

Fig.2, 4

 

phosphorylate Smad

transferase activity (GO:0016740)

ATP

SMAD2

phosphorylated SMAD2

Fig.2, 4

SMAD2

bind TβRI

TGF-beta receptor binding (GO:0005160)

TGFβ homodimer

TβRI homodimer

TGFβ-TβRII-TβRI-SMAD2 complex

Fig.4

 

SMAD2 activation

phosphate binding (GO:0042301)

ATP

SMAD2

phosphorylated SMAD2

Fig.4

 

Trimerize

protein heterodimerization activity (GO:0042803)

SMAD2

SMAD2 homodimer

Trimerized SMAD2

Fig.4

 

activate transcription

DNA binding (GO:0003677)

DNA

SMAD2

SMAD2-DNA complex

Fig.4