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Table 2 The gene product functions described herein are listed with their associated GO molecular functions and parameters. These gene product functions are mapped to corresponding Gene Ontology molecular functions. These GO functions are integrated into an object-oriented model by amending them with input and output parameters, thereby creating object functions.

From: Integration of the Gene Ontology into an object-oriented architecture

Gene Product Gene Product Function Corresponding GO Term and GO ID Input Output Figure Location
TGF-beta Dimerize protein homodimerization activity (GO:0042803) 2X TGF-beta Dimerized TGFβ Fig.4
  bind TGF-beta receptor TGF-beta receptor binding (GO:0005160) TGFβ homodimer
TGFβR homodimer
TGFβ-TGFβR complex Fig.4
TβRII Dimerize protein homodimerization activity (GO:0042803) 2X TβRII Dimerized RII Fig.4
  TGF-beta binding TGF-beta binding (GO:0060431) TβRII homodimer
TGFβ homodimer
TGFβ-TβRII heterotetramer Fig.2, 4
  Heterotetramerize protein heterodimerization activity (GO:0046982) TβRI homodimer
TβRII homodimer
TβRI-TβRII heterotetramer Fig.2, 4
  phosphorylate RI transferase activity (GO:0016740) ATP
TβRI homodimer
phosphorylated TβRI Fig.2, 4
TβRI Dimerize protein homodimerization activity (GO:0042803) 2X TβRI Dimerized RI Fig.4
  Heterotetramerize protein heterodimerization activity (GO:0046982) TβRI homodimer
TβRII homodimer
TβRI-TβRII heterodimer Fig.2, 4
  TβRI activation phosphate binding (GO:0042301) ATP
TβRI
phosphorylated TβRI Fig.4
  bind SMAD2 Smad binding (GO:0046332) SMAD2 TGFβ-TβRII-TβRI-SMAD2 complex Fig.2, 4
  phosphorylate Smad transferase activity (GO:0016740) ATP
SMAD2
phosphorylated SMAD2 Fig.2, 4
SMAD2 bind TβRI TGF-beta receptor binding (GO:0005160) TGFβ homodimer
TβRI homodimer
TGFβ-TβRII-TβRI-SMAD2 complex Fig.4
  SMAD2 activation phosphate binding (GO:0042301) ATP
SMAD2
phosphorylated SMAD2 Fig.4
  Trimerize protein heterodimerization activity (GO:0042803) SMAD2
SMAD2 homodimer
Trimerized SMAD2 Fig.4
  activate transcription DNA binding (GO:0003677) DNA
SMAD2
SMAD2-DNA complex Fig.4