From: Integration of the Gene Ontology into an object-oriented architecture
Gene Product | Gene Product Function | Corresponding GO Term and GO ID | Input | Output | Figure Location |
---|---|---|---|---|---|
TGF-beta | Dimerize | protein homodimerization activity (GO:0042803) | 2X TGF-beta | Dimerized TGFβ | Fig.4 |
 | bind TGF-beta receptor | TGF-beta receptor binding (GO:0005160) | TGFβ homodimer TGFβR homodimer | TGFβ-TGFβR complex | Fig.4 |
TβRII | Dimerize | protein homodimerization activity (GO:0042803) | 2X TβRII | Dimerized RII | Fig.4 |
 | TGF-beta binding | TGF-beta binding (GO:0060431) | TβRII homodimer TGFβ homodimer | TGFβ-TβRII heterotetramer | Fig.2, 4 |
 | Heterotetramerize | protein heterodimerization activity (GO:0046982) | TβRI homodimer TβRII homodimer | TβRI-TβRII heterotetramer | Fig.2, 4 |
 | phosphorylate RI | transferase activity (GO:0016740) | ATP TβRI homodimer | phosphorylated TβRI | Fig.2, 4 |
TβRI | Dimerize | protein homodimerization activity (GO:0042803) | 2X TβRI | Dimerized RI | Fig.4 |
 | Heterotetramerize | protein heterodimerization activity (GO:0046982) | TβRI homodimer TβRII homodimer | TβRI-TβRII heterodimer | Fig.2, 4 |
 | TβRI activation | phosphate binding (GO:0042301) | ATP TβRI | phosphorylated TβRI | Fig.4 |
 | bind SMAD2 | Smad binding (GO:0046332) | SMAD2 | TGFβ-TβRII-TβRI-SMAD2 complex | Fig.2, 4 |
 | phosphorylate Smad | transferase activity (GO:0016740) | ATP SMAD2 | phosphorylated SMAD2 | Fig.2, 4 |
SMAD2 | bind TβRI | TGF-beta receptor binding (GO:0005160) | TGFβ homodimer TβRI homodimer | TGFβ-TβRII-TβRI-SMAD2 complex | Fig.4 |
 | SMAD2 activation | phosphate binding (GO:0042301) | ATP SMAD2 | phosphorylated SMAD2 | Fig.4 |
 | Trimerize | protein heterodimerization activity (GO:0042803) | SMAD2 SMAD2 homodimer | Trimerized SMAD2 | Fig.4 |
 | activate transcription | DNA binding (GO:0003677) | DNA SMAD2 | SMAD2-DNA complex | Fig.4 |