Table 2 The gene product functions described herein are listed with their associated GO molecular functions and parameters. These gene product functions are mapped to corresponding Gene Ontology molecular functions. These GO functions are integrated into an object-oriented model by amending them with input and output parameters, thereby creating object functions.
From: Integration of the Gene Ontology into an object-oriented architecture
| Gene Product | Gene Product Function | Corresponding GO Term and GO ID | Input | Output | Figure Location |
|---|---|---|---|---|---|
| TGF-beta | Dimerize | protein homodimerization activity (GO:0042803) | 2X TGF-beta | Dimerized TGFβ | Fig.4 |
| bind TGF-beta receptor | TGF-beta receptor binding (GO:0005160) |
TGFβ homodimer TGFβR homodimer | TGFβ-TGFβR complex | Fig.4 | |
| TβRII | Dimerize | protein homodimerization activity (GO:0042803) | 2X TβRII | Dimerized RII | Fig.4 |
| TGF-beta binding | TGF-beta binding (GO:0060431) |
TβRII homodimer TGFβ homodimer | TGFβ-TβRII heterotetramer | Fig.2, 4 | |
| Heterotetramerize | protein heterodimerization activity (GO:0046982) |
TβRI homodimer TβRII homodimer | TβRI-TβRII heterotetramer | Fig.2, 4 | |
| phosphorylate RI | transferase activity (GO:0016740) |
ATP TβRI homodimer | phosphorylated TβRI | Fig.2, 4 | |
| TβRI | Dimerize | protein homodimerization activity (GO:0042803) | 2X TβRI | Dimerized RI | Fig.4 |
| Heterotetramerize | protein heterodimerization activity (GO:0046982) |
TβRI homodimer TβRII homodimer | TβRI-TβRII heterodimer | Fig.2, 4 | |
| TβRI activation | phosphate binding (GO:0042301) |
ATP TβRI | phosphorylated TβRI | Fig.4 | |
| bind SMAD2 | Smad binding (GO:0046332) | SMAD2 | TGFβ-TβRII-TβRI-SMAD2 complex | Fig.2, 4 | |
| phosphorylate Smad | transferase activity (GO:0016740) |
ATP SMAD2 | phosphorylated SMAD2 | Fig.2, 4 | |
| SMAD2 | bind TβRI | TGF-beta receptor binding (GO:0005160) |
TGFβ homodimer TβRI homodimer | TGFβ-TβRII-TβRI-SMAD2 complex | Fig.4 |
| SMAD2 activation | phosphate binding (GO:0042301) |
ATP SMAD2 | phosphorylated SMAD2 | Fig.4 | |
| Trimerize | protein heterodimerization activity (GO:0042803) |
SMAD2 SMAD2 homodimer | Trimerized SMAD2 | Fig.4 | |
| activate transcription | DNA binding (GO:0003677) |
DNA SMAD2 | SMAD2-DNA complex | Fig.4 |