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Figure 1 | BMC Bioinformatics

Figure 1

From: PAGE: Parametric Analysis of Gene Set Enrichment

Figure 1

Distribution pattern of fold change values in a microarray data and determination of minimal gene set size in PAGE. A and B. A Histogram (A) and a quantile-quantile (Q-Q) plot against standard normal distribution (B) of fold change values from microarray data set. The diabetic muscle microarray data set [25] was analyzed as described in Methods section. The fold change values between normal and patient groups were calculated and used to draw histogram (A) and Q-Q plot (B). C and D. A Histrogram (C) and a Q-Q plot (D) of an average of 10 randomly sampled values from fold change values of diabetic muscle microarray data. Kolmogorov-Smirnov normality test was performed with a null hypothesis that distribution is normal. For the distribution of fold change values (A and B), the null hypothesis was rejected (D = 0.08, p-value < 2.2e-16). For the distribution of an average of 10 randomly sampled values from fold change values (C and D), the null hypothesis was not rejected (D = 0.0239, p-value = 0.1783).

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