Figure 2

Calculation of p ₀ and estimations of λ from a simulation study. 10,000 p-values were simulated in a mixture of an alternative and a null distribution. As functions of λ ∈ [1, 100] and π₀ ∈ [0, 1] are shown: (A) , (B) the relative error in , (C) the proportion of false positives (PFP) and (D) false negatives (PFN) when selecting the genes with p <p₀. NB the inverse arrow of π₀ in (C).