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Figure 3 | BMC Bioinformatics

Figure 3

From: Dissecting systems-wide data using mixture models: application to identify affected cellular processes

Figure 3

Comparisons between p 0 and other selection methods in a simulation study. 10,000 p-values were simulated in a mixture of an alternative and a null distribution. The proportions of false positives (A) and false negatives (B) are depicted as functions of λ [1, 100], π0 is set at 0.67. Selecting the genes with p <p0 (black) is compared to: selecting the genes with p < 0.001 (brown) or p < 0.1 (red); controlling the Benjamini-Hochberg FDR at α = 0.05 (dark blue) or α = 0.2 (light blue); the Benjamini-Yekutieli FDR at α = 0.2 (dark green) and the FWER at α = 0.2 (light green). The lines represent means of twenty simulations.

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