Figure 4
Enrichment of gene sets in the BRCA-study. Genes R1, ..., RN (N > 3,000) are ordered on their p-values and the cumulative sum is calculated to determine whether the members of a gene set are enriched. Starting with the top-ranking gene, the sum increases when a gene in the gene set is encountered and decreases otherwise. The gene sets shown here are (A) cell cycle (solid line – BRCA1-sporadic; dashed line – BRCA2-sporadic) and (B) DNA repair (solid line – BRCA1-sporadic; dashed line – BRCA2-sporadic). (C) For the comparison BRCA1/2-sporadic, the gene sets consisting of genes functional in the mitochondria (solid line) and electron transport (dashed line) are depicted. The vertical dotted lines correspond to the thresholds, p0, for BRCA1, BRCA2 and BRCA1/2 compared to sporadic.