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Table 2 Disulfied intermediates experimentally observed in the oxidative folding of various proteins

From: Graph-representation of oxidative folding pathways

Protein

Disulfide intermediates1

Ref.

Bovine pancreatic trypsin inhibitor (BPTI)

3–5; 1–6; 3–5, 1–2;

3–5, 1–4; 3–5, 2–4;

1–6, 2–4; 3–5, 1–6;

1–6, 3–5, 2–4;

[26, 27]

Insulin-like growth factor (IGF)

2–6; 2–6, 3–5; 2–6, 1–4;

2–6, 4–5; 2–6, 1–3;

2–6, 1–3, 4–5; 1–4, 2–6, 3–5;

[28-30]

Epidermal growth factor (EGF)

2–3; 1–2; 4–6; 5–6;

3–4; 2–4, 5–6; 2–5, 3–4;

1–6, 2–5, 3–4; 1–2, 3–4, 5–6;

1–3, 2–4, 5–6;

[31]

  1. 1The intermediates are described with the notation given in Figure 2. The native disulfide connectivity is in bold, the fully reduced species is not included.