Figure 2

Significantly matching residues on proteins sharing no structural or sequence similarity. Similarity detected comparing the SURFACE database of annotated functional sites against a list of annotated monomers (a,b) or proteins with unknown function from structural genomics projects (c,d,e,f); the annotated patch residues are colored in blue, the matching residues in red; whenever possible, the patch annotation (bound ligand or PROSITE pattern) is shown. (a) Similarity detected between the E. coli UDP-galactose 4-epimerase (PDB code 1nah) NADH-binding patch and the H. influenzae YecO methyltransferase (1im8); the NAD co-crystallized with 1nah is shown; the similarity involves 7 residues (with a Z-score 9.06). (b) Structural similarity between the HEXOKINASES PROSITE pattern-annotated patch of the human hexokinase type I (1qha) and the bacteriophage ms2 capsid protein; additional 1qha annotated residues are shown in yellow. (c) Structural similarity detected between the B. subtilis Yqvk protein, and the Wolinella succinogenes fumarate reductase cytochrome B subunit heme group binding patch. (d) Match between Hi1480 protein from Haemophilus influenzae and the bovine cytochrome Bc1 heme-binding patch. (e) Similarity between the B. subtilis protein Yqeu and the E. coli Grea transcript cleavage factor GREAB_1-annotated patch; additional pattern-annotated residues are shown in yellow. (e) Similarity between E. coli lysozyme inhibitor and two ATP-binding patches, the Rattus norvegicus 6-Phosphofructo-2-Kinase/ Fructose-2,6-Bisphosphatase major patch (red) and the mouse Aaa ATPase P97 (green).