Table 1 Structural matches Z-score distribution and validation. This Table shows the number of structural matches (second column from the left) found as a function of the Z-score of the match. The third column from the left (labeled "validated") reports the number of matches for which at least one of the validation criteria holds. The following columns show a breakdown of the number of matches validated by each validation condition (from the fourth column on the left to the rightmost: same PROSITE pattern annotation; same binding ability; common GO term annotation; same SCOP fold; same Enzyme Classification number; sequence similarity at least 40%; common SwissProt keyword). Note that the sum of the matches validated by the different criteria for each row is higher than the total number of validated matches at that given Z-score, since some matches can satisfy more than one condition. At increasing Z-scores, the ratio of validation condition that we consider less reliable (SwissProt keywords, GO terms) decreases, while the ratio of more reliable annotations (i.e. same binding ability, same PROSITE pattern annotation) increases.

From: Functional annotation by identification of local surface similarities: a novel tool for structural genomics