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Table 1 Structural matches Z-score distribution and validation. This Table shows the number of structural matches (second column from the left) found as a function of the Z-score of the match. The third column from the left (labeled "validated") reports the number of matches for which at least one of the validation criteria holds. The following columns show a breakdown of the number of matches validated by each validation condition (from the fourth column on the left to the rightmost: same PROSITE pattern annotation; same binding ability; common GO term annotation; same SCOP fold; same Enzyme Classification number; sequence similarity at least 40%; common SwissProt keyword). Note that the sum of the matches validated by the different criteria for each row is higher than the total number of validated matches at that given Z-score, since some matches can satisfy more than one condition. At increasing Z-scores, the ratio of validation condition that we consider less reliable (SwissProt keywords, GO terms) decreases, while the ratio of more reliable annotations (i.e. same binding ability, same PROSITE pattern annotation) increases.

From: Functional annotation by identification of local surface similarities: a novel tool for structural genomics

Z-score Total Validated PROSITE Ligand GO Scop E.C. Seq. sim. SwissProt kw
3.0 31341 7066 366 951 3565 765 99 2 5655
3.5 14948 4002 747 830 2222 889 48 3 2944
4.0 9721 2814 557 613 1680 788 44 1 2043
4.5 3942 1346 440 467 841 390 32 1 989
5.0 1549 764 281 234 436 411 5 1 514
5.5 976 612 287 181 320 399 7 0 342
6.0 639 457 177 209 267 271 3 0 323
6.5 621 548 279 258 298 447 4 0 383
7.0 365 328 157 115 180 246 2 0 200
7.5 260 219 105 68 109 176 6 1 152
8.0 270 238 104 87 149 191 0 1 169
8.5 209 195 80 57 129 153 8 1 131
9.0 122 107 54 54 70 87 0 0 63
9.5 137 129 60 48 74 119 0 0 80
10.0 124 113 53 61 75 104 0 1 86
10.5 55 51 17 22 29 43 2 0 36
11.0 106 103 46 40 65 91 4 0 66
11.5 88 88 42 43 65 80 5 0 55
12.0 78 77 33 34 51 75 5 0 52
12.5 71 69 26 32 38 64 5 1 54
13.0 49 47 30 21 24 45 0 0 30
13.5 39 39 9 19 17 39 1 0 24
14.0 29 29 14 16 18 29 3 0 25