Table 1 Dominantly inherited neurodegenerative diseases are associated with abnormally expanded tracts of glutamine residues.
From: COPASAAR – A database for proteomic analysis of single amino acid repeats
Disease protein | Gln repeats | Other notable repeats/comments |
|---|---|---|
Huntington's disease protein | 1 SAAR (23-residues) | 2x Pro repeats (11-and 10-residues) 2x Glu repeats (6-and 5-residues) |
Spinocerebellar ataxin type 1 | 2 SAARs (15-and 12-residues) | The two Gln repeats are separated by 4 residues |
Androgen receptor (Kennedy's disease) | 3 SAARs (21-, 6-and 5-residues) | 1x Pro repeat (8-residues) 1x Ala repeat (5-residues) 1x Gly repeat (24-residues) |