Skip to main content
Figure 2 | BMC Bioinformatics

Figure 2

From: Improved prediction of critical residues for protein function based on network and phylogenetic analyses

Figure 2

Comparison between phylogenetic, random and network methods. We compare method 1 (based on closeness centrality) with two phylogenetic methods (method 7 -Hssp database- and method 8 -Conseg server-) and with a random selection of the amino acids. There is a probability less than 1% (resp. 0.5%) that a random selection of the amino acids will produce a curve over the "Random <1%" curve (resp. "Random <0.5%" curve). We notice that if we predict between 10% and 50% of the amino acids, there is a probability less than 0.5% that a random selection of the amino acids will give better results than methods 1 and 7. The calculations are made as an average over the five networks representing HIV-1 protease, TEM1 beta-lactamase, T4 lysozyme, Barnase and the bacteriophage f1 gene V protein.

Back to article page