Figure 6

Relationship between some network-based centrality measurements and the surface area for TEM1 beta-lactamase. For each amino acid of TEM1 beta-lactamase (1BTL), we plot four network centrality measurements (closeness centrality, betweenness, connectivity and 2-connectivity) versus the surface area. The "best cut-off curve corresponds to the cut-off that minimizes the dist(centr. meas., cut-off) error. In other words, for the four centrality measurements, the best result is obtained by predicting an amino acid to be critical if it is above this line (the corresponding set of predicted amino minimizes the error dist(centr. meas.,cut-off)).