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Table 2 Estimated Sensitivity and Specificity for closeness centrality

From: Improved prediction of critical residues for protein function based on network and phylogenetic analyses

Protein(s)

Sensitivity

Specificity

1BTL

67.4%

72.7%

1HIV

58.7%

83.0%

2LZM

68.3%

78.8%

1A2P

75.0%

89.4%

1GVP

87.5%

64.5%

Average(lBTL, lHIV, 2LZM, lA2P, lGVP)

71.4%

77.7%

Average(128 proteins set)

63.9%

64.1%

  1. The sensitivity and specificity values are reported for each individual protein (1BTL, 1HIV, 2LZM, 1A2P and 1GVP), and the average values obtained for these proteins and the set of 128 proteins. These sensitivity and specificity values correspond to the best cut-off value of the error (i.e. smallest dist(centr. meas., cut-off)) estimated for the closeness centrality. Results in average are obtained by taking the best cut-off value for every protein (and not by taking a fixed cut-off as in Table 1).
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BMC Bioinformatics

ISSN: 1471-2105

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