This figure shows the trees obtained either with ClustalW/PHYLIP (a) or with the JACOP protocol (b). The families of enzymes with different activities are presented in different colours. The resulting independent groups and subgroups found by JACOP are indicated by frames. In the case of the tree obtained with the JACOP protocol, the resampling/bootstrap values above 95% are indicated. The separation (*) between the three subgroups of homologues received a relatively low value because of comparable distances that induce a competition of sub-tree topology at that node.