The folic acid biosynthesis pathway from the reconstructed metabolic network of Saccharomyces Cerevisiae . Reproduced with permission from Cold Spring Harbor Laboratory ©2004 (Duarte et al. 2004 ). The EC numbers and the genes associated with the reactions were added to diagram. The parts that overlap with the MetaCyc folic acid biosynthesis pathway are circled. The green circles indicate consistency while the red one indicates inconsistency.