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Figure 2 | BMC Bioinformatics

Figure 2

From: Proteins with two SUMO-like domains in chromatin-associated complexes: The RENi (Rad60-Esc2-NIP45) family

Figure 2

Ribbon diagram of the human SUMO-1 protein structure [21]. The displayed region corresponds to the segment shown in the alignment in Figure 1. The core residues L24, I34, F36, F64, F66, I88 located in the beta-strands and L44, L47, K48, Y51, Q55 in the helix form critical contacts in the helix-sheet interface of the SUMO core. These residues are shown in the stick mode (in purple). The highlighted Q55 and F66 residues align with residues mutated in the rad60-1 (K263E) [15] and rad60-3 (F272V) [20] variants (see also Figure 1).

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