Figure 4

Example of four adjacent coexpressed genes. Shown is the gene cluster distribution on human chromosome 2 with an example of four adjacent genes regulated in part by common transcription factors and sharing gene ontology categories. Coexpressed gene clusters are shown in red. Each coexpressed gene pair ABI2 – RAPH1; RAPH1 – CD28 and CD28 – CTLA4 shares GO terms as indicated. Genes of the triplet RAPH1 – CD28 – CTLA4 have transcription factor binding sites for AP3 and EV1 in common. Furthermore, each gene pair RAPH1 – CD28 and CD28 – CTLA4 shares additional TFBS. Genes are marked in green, arrows indicate the strand orientation, promotor regions and transcription factors are colored in yellow.