Figure 3
From: Sequence variation in ligand binding sites in proteins
Effects of sample size. (a) Average relative entropy associated with each of the 34 positions in TPRs with random subsets of various sizes. Each cluster of bars represents one position in the TPR motif. The cluster is composed of bars, left to right, from sets with approximately 6887, 3444, 1722, 861, 430, 215 and 108 sequences. Each bar is the average of five subsets of the same size (except 6887, since there is only one set this size – all sequences). (b) Relative entropies associated with five randomly chosen subsets of various sizes for the seven positions most like the reference state. Each cluster of bars represents one position. The individual bars show the calculated relative entropies for subsets of the same sizes as in (a) (five of each size).