Skip to main content

Advertisement

Figure 7 | BMC Bioinformatics

Figure 7

From: The modeled structure of the RNA dependent RNA polymerase of GBV-C Virus suggests a role for motif E in Flaviviridae RNA polymerases

Figure 7

Docking a GTP in the GBV-C polymerase. A to C: Views of GTP-binding pockets. The surface is colored according to the electrostatic potential nomenclature. Hydrogen bonds are indicated in dotted lines and the numbering indicates the distance (in Å) between amino acids. A: The proposed GTP pocket in the GBV-C polymerase model with a docked GTP molecule. B: The BVDV polymerase structure in which a GTP molecule is co-crystallized. C: The proposed GTP pocket in the HCV polymerase structure with a docked GTP molecule. D to F: LIGPLOT presenting residues involved in the stabilization of GTP. Hydrogen bonds are indicated in dotted lines and the numbering indicates the distance (in Å) between amino acids. D: View of the GBV-C GTP pocket. E: same view of the BVDV GTP pocket. F: LIGPLOT of the HCV GTP pocket. Images were generated using PYMOL.

Back to article page