| Cluster One (1187) |
---|---|
P-Value | Ontology Term |
0.0003 | DNA dependent DNA replication |
0.0003 | mitotic cell cycle |
0.0008 | DNA replication |
0.001 | structural constituent of cytoskeleton |
0.0014 | metabolism |
0.0015 | proteolysis and peptidolysis |
0.0016 | cell cycle |
0.0016 | hydrolase activity |
0.0016 | S phase of mitotic cell cycle |
0.0021 | protein metabolism |
0.0024 | protein catabolism |
0.0028 | DNA replication and chromosome cycle |
0.0029 | small ribosomal subunit |
0.0031 | intracellular |
0.0031 | extracellular |
0.004 | DNA replication factor C complex |
0.0059 | nucleic acid binding activity |
0.0059 | ATP dependent helicase activity |
0.006 | transmembrane receptor protein phosphatase activity |
0.006 | transmembrane receptor protein tyrosine phosphatase activity |
0.0061 | cell proliferation |
0.0063 | mitochondrial inner membrane |
0.0065 | extracellular space |
0.0065 | macromolecule catabolism |
0.0071 | protein phosphatase activity |
0.0073 | nucleobase, nucleoside, nucleotide and nucleic acid metabolism |
0.0074 | replication fork |
0.0078 | protein amino acid dephosphorylation |
0.0078 | dephosphorylation |
0.0078 | protein-ligand dependent protein catabolism |
0.0081 | mitochondrial ribosome |
0.009 | inner membrane |
0.0092 | mitochondrion |
0.0095 | cellular_component unknown |
0.0111 | helicase activity |
0.0113 | organellar ribosome |
0.0123 | N-linked glycosylation |
0.0123 | di-, tri-valent inorganic cation homeostasis |
0.014 | proton-transporting ATP synthase complex |
0.014 | spindle |
 | Cluster Nine (724) |
P-Value | Ontology Term |
0.0003 | mitochondrion |
0.0005 | metabolism |
0.0008 | intracellular |
0.0018 | biosynthesis |
0.0022 | complement activation, alternative pathway |
0.003 | complement activation |
0.0044 | complement activity |
0.0047 | sugar binding activity |
0.0047 | carbohydrate binding activity |
0.006 | humoral defense mechanism (sensu Vertebrata) |
0.0067 | plasma membrane |
0.007 | cell adhesion molecule activity |
0.0071 | 1-phosphatidylinositol 3-kinase complex |
0.0071 | membrane attack complex |
0.0071 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances |
0.0071 | phosphatidylinositol 3-kinase activity |
0.0079 | ATP-binding cassette (ABC) transporter activity |
0.0098 | cell adhesion |
0.0099 | chemotaxis |
0.0099 | taxis |
0.0125 | cell-cell adhesion |
0.013 | mitochondrial membrane |
0.0151 | lectin |
0.0156 | G-protein coupled receptor protein signaling pathway |
0.0176 | cellular_component unknown |
0.0187 | P-P-bond-hydrolysis-driven transporter activity |
0.02 | thyroid hormone generation |
0.02 | lipid raft |
0.02 | ethanol oxidation |
0.02 | ethanol metabolism |
0.02 | flowering |
0.02 | thyroid hormone metabolism |
0.02 | aldo-keto reductase activity |
0.02 | alcohol dehydrogenase activity, iron-dependent |
0.02 | alcohol dehydrogenase activity, metal ion-independent |
0.02 | T-cell differentiation |
0.02 | negative regulation of Wnt receptor signaling pathway |
0.02 | fluid secretion |
0.022 | homophilic cell adhesion |
0.0266 | humoral immune response |
 | Cluster Four (271) |
P-Value | Ontology Term |
0.0002 | cytoplasm |
0.001 | transcription |
0.0012 | regulation of transcription, DNA-dependent |
0.0013 | regulation of transcription |
0.0015 | transcription, DNA-dependent |
0.0029 | immune response |
0.0029 | nucleus |
0.0034 | transferase activity, transferring sulfur-containing groups |
0.0034 | solute:sodium symporter activity |
0.005 | defense response |
0.0051 | phenol metabolism |
0.0051 | catecholamine metabolism |
0.0051 | organic acid transporter activity |
0.0053 | cell communication |
0.0055 | response to biotic stimulus |
0.0059 | protein modification |
0.0063 | protein kinase CK2 activity |
0.0069 | solute:cation symporter activity |
0.0071 | response to external stimulus |
0.0084 | negative regulation of transcription |
0.0093 | biogenic amine metabolism |
0.0093 | adherens junction |
0.0096 | cAMP-dependent protein kinase activity |
0.0096 | cyclic-nucleotide dependent protein kinase activity |
0.0096 | casein kinase activity |
0.0097 | transcription from Pol II promoter |
0.0099 | secretin-like receptor activity |
0.0099 | neurotransmitter:sodium symporter activity |
0.0099 | neurotransmitter transporter activity |
0.0099 | biogenic amine biosynthesis |
0.0103 | protein amino acid phosphorylation |
0.0106 | G-protein coupled receptor activity |
0.0112 | neurogenesis |
0.0119 | transmembrane receptor protein serine/threonine kinase signaling pathway |
0.0128 | phosphorylation |
0.0139 | small GTPase mediated signal transduction |
0.0141 | protein kinase activity |
0.0151 | brain development |
0.016 | frizzled receptor signaling pathway |
0.016 | frizzled receptor activity |
 | Cluster Ten (815) |
P-Value | Ontology Term |
<.0001 | nucleobase, nucleoside, nucleotide and nucleic acid metabolism |
<.0001 | nucleus |
<.0001 | intracellular |
<.0001 | extracellular space |
<.0001 | extracellular |
<.0001 | RNA binding activity |
<.0001 | nucleic acid binding activity |
0.0001 | plasma glycoprotein |
0.0001 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor |
0.0003 | oxidoreductase activity, acting on the CH-NH2 group of donors |
0.0003 | molecular_function |
0.0003 | alpha-type channel activity |
0.0004 | response to external stimulus |
0.0004 | channel/pore class transporter activity |
0.0005 | chymotrypsin activity |
0.0005 | RNA metabolism |
0.0007 | trypsin activity |
0.0011 | metabolism |
0.0014 | immune response |
0.0015 | defense response |
0.0016 | RNA processing |
0.0025 | response to biotic stimulus |
0.0028 | cell surface receptor linked signal transduction |
0.0028 | integral to membrane |
0.0031 | regulation of transcription |
0.0032 | transcription |
0.0037 | signal transducer activity |
0.0039 | translation regulator activity |
0.004 | regulation of transcription, DNA-dependent |
0.004 | membrane |
0.0042 | voltage-gated ion channel activity |
0.0044 | ligand-dependent nuclear receptor activity |
0.0044 | potassium channel activity |
0.0044 | steroid hormone receptor activity |
0.0045 | ion transport |
0.005 | small GTPase mediated signal transduction |
0.0051 | nucleoplasm |
0.0052 | cation channel activity |
0.0054 | digestion |
0.0058 | ligand-regulated transcription factor activity |
 | Cluster Six (474) |
P-Value | Ontology Term |
0.0002 | development |
0.0002 | extracellular matrix structural constituent |
0.0003 | muscle development |
0.0004 | muscle contraction |
0.0007 | intramolecular isomerase activity |
0.0013 | cell differentiation |
0.0014 | mitochondrion |
0.002 | cellular process |
0.002 | organogenesis |
0.0022 | cell adhesion |
0.0027 | cytoskeleton |
0.0032 | oncogenesis |
0.0032 | structural constituent of cytoskeleton |
0.0033 | cell communication |
0.0036 | morphogenesis |
0.0037 | troponin complex |
0.0037 | NGF/TNF (6 C-domain) receptor activity |
0.0042 | circulation |
0.0046 | structural molecule activity |
0.0048 | actin cytoskeleton |
0.0049 | cell motility |
0.005 | muscle fiber |
0.0056 | photoreceptor activity |
0.0056 | G-protein coupled photoreceptor activity |
0.0056 | collagen type I |
0.011 | intermediate filament cytoskeleton |
0.011 | intermediate filament |
0.0125 | transcription cofactor activity |
0.0128 | extracellular matrix structural constituent conferring tensile strength activity |
0.0128 | sarcomere |
0.0128 | myofibril |
0.0128 | collagen |
0.0139 | response to stress |
0.0149 | hydrolase activity |
0.016 | intramolecular isomerase activity, interconverting aldoses and ketoses |
0.016 | phosphagen metabolism |
0.016 | neurofilament |
0.016 | galactose binding lectin |
0.016 | inactivation of MAPK |
0.0176 | striated muscle thin filament |
 | Cluster Twelve (619) |
P-Value | Ontology Term |
<.0001 | cell communication |
0.0001 | signal transduction |
0.0078 | development |
0.0103 | phosphate metabolism |
0.0103 | phosphorus metabolism |
0.0159 | neurogenesis |
0.016 | cell adhesion |
0.0179 | intracellular signaling cascade |
0.0196 | amino acid transport |
0.0311 | small GTPase mediated signal transduction |
0.0384 | coreceptor activity |
0.0464 | heme-copper terminal oxidase activity |
0.0464 | acute-phase response |
0.0464 | regulation of metabolism |
0.0476 | cell-cell signaling |
0.085 | beta3-adrenergic receptor activity |
0.085 | purine ribonucleoside catabolism |
0.085 | purine ribonucleoside metabolism |
0.085 | pentose catabolism |
0.085 | pentose metabolism |
0.085 | ribose catabolism |
0.085 | adenosine metabolism |
0.085 | manganese ion transport |
0.085 | ADP-sugar diphosphatase activity |
0.085 | bile acid biosynthesis |
0.0858 | cellular respiration |
0.094 | organelle organization and biogenesis |
0.0966 | alcohol catabolism |
0.1096 | xenobiotic metabolism |
0.1096 | neuropeptide signaling pathway |
0.1105 | meiosis |
0.1136 | deaminase activity |
0.1198 | synaptic transmission |
0.1215 | transmission of nerve impulse |
0.1314 | monovalent inorganic cation transporter activity |
0.1491 | chloride transport |
0.1627 | internalization receptor activity |
0.1627 | regulation of mitotic cell cycle |
0.1627 | cAMP metabolism |
0.1627 | regulation of cell volume |
 | Cluster Thirteen (1208) |
P-Value | Ontology Term |
0.0002 | mitochondrion |
0.0004 | intracellular |
0.0008 | metabolism |
0.0012 | extracellular |
0.0026 | DNA repair |
0.0031 | immune response |
0.0041 | extracellular space |
0.0045 | phosphatidylinositol transporter activity |
0.0061 | cytosolic large ribosomal subunit (sensu Eukarya) |
0.0065 | defense response |
0.0069 | nucleobase, nucleoside, nucleotide and nucleic acid metabolism |
0.0071 | RNA binding activity |
0.0078 | large ribosomal subunit |
0.0083 | heme biosynthesis |
0.0083 | sex determination |
0.0095 | G-protein coupled receptor protein signaling pathway |
0.0097 | integral to membrane |
0.0098 | biosynthesis |
0.0101 | integral to plasma membrane |
0.0109 | mitotic cell cycle |
0.0147 | pigment biosynthesis |
0.0147 | post Golgi transport |
0.015 | nucleus |
0.0157 | cyclohydrolase activity |
0.0157 | protein amino acid methylation |
0.0157 | RNA-nucleus export |
0.0157 | transferase activity, transferring pentosyl groups |
0.0169 | porphyrin biosynthesis |
0.0169 | chromatin remodeling complex |
0.0169 | heme metabolism |
0.0178 | plasma membrane |
0.0192 | S phase of mitotic cell cycle |
0.0193 | coenzymes and prosthetic group biosynthesis |
0.0209 | cell surface receptor linked signal transduction |
0.021 | ion transport |
0.0233 | trypsin activity |
0.0234 | pigment metabolism |
0.0236 | inorganic anion transport |
0.0266 | apoptosis regulator activity |
0.0268 | nucleic acid binding activity |
 | Cluster Fifteen (725) |
P-Value | Ontology Term |
0.0007 | blood vessel development |
0.0007 | angiogenesis |
0.001 | phosphotransferase activity, alcohol group as acceptor |
0.0013 | nuclear localization sequence binding activity |
0.0017 | protein kinase activity |
0.002 | response to pest/pathogen/parasite |
0.0023 | protein serine/threonine kinase activity |
0.0024 | kinase activity |
0.0025 | cellular process |
0.0028 | cell migration |
0.0038 | actin polymerization and/or depolymerization |
0.0048 | spermatid development |
0.0048 | NLS-bearing substrate-nucleus import |
0.0048 | galactosyltransferase activity |
0.0051 | signal transduction |
0.0053 | protein tyrosine kinase activity |
0.0059 | embryogenesis and morphogenesis |
0.006 | neurogenesis |
0.007 | immune response |
0.0073 | cell-matrix adhesion |
0.0073 | nucleotide binding activity |
0.0077 | Golgi apparatus |
0.0079 | transferase activity, transferring phosphorus-containing groups |
0.0088 | phosphate metabolism |
0.0088 | phosphorus metabolism |
0.0091 | protein amino acid phosphorylation |
0.0097 | response to wounding |
0.0097 | response to biotic stimulus |
0.0106 | phosphorylation |
0.0111 | RAN protein binding activity |
0.0112 | morphogenesis |
0.0113 | development |
0.0113 | purine nucleotide binding activity |
0.012 | actin filament-based process |
0.0121 | importin, beta-subunit |
0.0121 | actin modulating activity |
0.0121 | actin monomer binding activity |
0.0121 | regulation of actin polymerization and/or depolymerization |
0.0124 | cytoskeleton organization and biogenesis |
0.0137 | cell communication |
 | Cluster Sixteen (1266) |
P-Value | Ontology Term |
0.0004 | immune response |
0.0008 | oncogenesis |
0.0009 | defense response |
0.0042 | ionic insulation of neurons by glial cells |
0.0125 | inflammatory response |
0.0245 | histogenesis and organogenesis |
0.0261 | sarcomere alignment |
0.0261 | phagocytosis, engulfment |
0.0261 | negative regulation of osteoclast differentiation |
0.0261 | regulation of osteoclast differentiation |
0.0261 | negative regulation of cell differentiation |
0.0261 | NO mediated signal transduction |
0.0326 | activation of NF-kappaB-inducing kinase |
0.0327 | oogenesis |
0.0453 | cell activation |
0.0483 | humoral immune response |
0.0491 | protein modification |
0.0575 | regulation of cell differentiation |
0.0673 | cell cycle |
0.07 | biotin metabolism |
0.0806 | phosphate metabolism |
0.0806 | phosphorus metabolism |
0.0888 | sensory organ development |
0.0888 | G-protein signaling, adenylate cyclase activating pathway |
0.1073 | pattern specification |
0.1111 | gametogenesis |
0.119 | peptide receptor activity |
0.1221 | microtubule-based process |
0.1251 | phosphate transport |
0.1251 | glutathione conjugation reaction |
0.1251 | G-protein chemoattractant receptor activity |
0.1256 | phagocytosis |
0.1256 | carbohydrate kinase activity |
0.1299 | regulation of transcription |
0.1309 | fatty acid metabolism |
0.1435 | antimicrobial humoral response (sensu Invertebrata) |
0.1435 | protein amino acid phosphorylation |
0.1454 | NIK-I-kappaB/NF-kappaB cascade |
0.1507 | protein phosphatase type 2C activity |
0.1507 | heavy metal ion transport |