Table 1 Correlation between alternative splicing (AS) and protein-protein interactions (PPI). Expected numbers under independency assumption are given in parentheses. "EST-N" denotes isoforms with each exon supported by ESTs from at least N clone libraries.
protein data, χ2 = 11.17 | No PPI | At least one PPI | TOTAL |
|---|---|---|---|
No AS | 5434 (5408) | 122 (= 83% of 148) | 5556 |
At least two AS-isoforms | 3692 (3718) | 127 (= 125% of 101) | 3819 |
TOTAL | 9126 | 249 | 9375 |
mRNA data, χ2 = 9.05 | No PPI | At least one PPI | TOTAL |
No AS | 4879 (4856) | 107 (= 82% of 130) | 4986 |
At least two AS-isoforms | 4360 (4383) | 141 (= 120% of 118) | 4501 |
TOTAL | 9239 | 248 | 9487 |
EST-5 data, χ2 = 6.57 | No PPI | At least one PPI | TOTAL |
No AS | 4463 (4443) | 99 (= 83% of 119) | 4562 |
At least two AS-isoforms | 4804 (4324) | 149 (= 115% of 129) | 4953 |
TOTAL | 9267 | 248 | 9515 |
EST-3 data, χ2 = 7.79 | No PPI | At least one PPI | TOTAL |
No AS | 4001 (3979) | 85 (= 80% of 107) | 4086 |
At least two AS-isoforms | 5302 (5324) | 164 (= 115% of 142) | 5466 |
TOTAL | 9303 | 249 | 9552 |
EST-2 data, χ2 = 7.57 | No PPI | At least one PPI | TOTAL |
No AS | 3299 (3278) | 68 (= 77% of 89) | 3367 |
At least two AS-isoforms | 6063 (6084) | 185 (= 113% of 164) | 6248 |
TOTAL | 9362 | 253 | 9615 |
normalized data, χ2 = 7.23 | No PPI | At least one PPI | TOTAL |
No AS | 2275 (2257) | 42 (= 70% of 60) | 2317 |
At least two AS-isoforms | 7066 (7084) | 206 (= 110% of 188) | 7272 |
TOTAL | 9341 | 248 | 9589 |