Figure 3

a. Interplay between 24 of the hubs identified by HubView constituting the signaling backbone. Red hubs are deemed as lethal knockout phenotypes as described in the systematic deletion project [35]. The nodes are separated by degree along the ordinate to illustrate a possible relationship between the degree of a hub and its phylogenetic age while the arrangement along the abscissa is purely aesthetic. The proposed function of the 3 clusters from left to right are: DNA damage/repair, cell cycle propagation and pheromone response. b. The dendrogram to the right confirms functional interactions for a number of the backbone hubs using redundancy clustering of the entire KPI as described by Samanta & Liang [28]. Only clusters containing a hub kinase are depicted in the dendrogram.