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Table 1 Summary of hub kinases as identified by Hubview: Weighted mean calculated by giving double weight to degrees listed in the core KPI dataset. Hubs with knockout lethal phenotype listed as identified by Giaver et al [35].

From: The yeast kinome displays scale free topology with functional hub clusters

Name

DIP Node Number

Knockout Lethal

Weighted Degree

Confidence as a super-hub

CDC28

DIP:1039N

yes

150 ± 40

High

CKA1

DIP:48N

no

50 ± 10

High

HRR25

DIP:157N

yes

40 ± 10

High

SLT2

DIP:1448N

no

37 ± 5

High

YCK1

DIP:719N

no

34 ± 7

High

KSS1

DIP:60N

no

33 ± 5

High

SNF1

DIP:18N

no

24 ± 1

High

PHO85

DIP:1493N

no

22 ± 2

High

RAD53

DIP:2322N

yes

22 ± 2

High

CKB2

DIP:262N

no

19 ± 5

High

CDC7

DIP:1235N

yes

19 ± 6

High

RIM11

DIP:1566N

no

19 ± 3

High

SSN3

DIP:2574N

no

17

High

DBF2

DIP:2319N

no

17 ± 2

High

DUN1

DIP:1772N

no

16 ± 6

Uncertain

MKK2

DIP:1447N

no

16 ± 2

High

CDC5

DIP:2321N

yes

14 ± 1

High

STE11

DIP:861N

no

14 ± 1

High

PKC1

DIP:1516N

yes

14 ± 1

High

TPK3

DIP:550N

no

14 ± 1

High

CKA2

DIP:1038N

no

13 ± 5

Uncertain

SPS1

DIP:6598N

no

13 ± 2

Uncertain

CLA4

DIP:2276N

no

13

Uncertain

YAK1

DIP:1374N

no

12 ± 4

Uncertain

STE20

DIP:712N

no

12 ± 1

Uncertain

FUS3

DIP:714N

no

12 ± 1

Uncertain

CHK1

DIP:1253N

no

12 ± 2

Uncertain

KIN2

DIP:6276N

no

12 ± 2

Uncertain

BUD32

DIP:5008N

no

11 ± 9

Uncertain

SWE1

DIP:2410N

no

11

Low

CKB1

DIP:282N

no

11 ± 7

Uncertain

GIN4

DIP:2260N

no

11 ± 1

Low

BCY1

DIP:551N

no

10 ± 3

Low