Table 2 Parameter optimization of the distance-profile method: performance indices based on the training set. The normalized performance indices are given in parentheses and expressed in percentages. For instance, the ROC1-S and TFF indices obtained under the Ppvalue representation with zscore threshold Ï„= 4 and L2 distance metric amount to 267 and 363, respectively. The PD measure was evaluated only for Ï„= 3 to 4.5.
Index | Ï„ | Association measure/Distance metric | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Â | Â | zscore | pvalue | prob | |||||
| Â | Â | L 1 | L 2 | L 1 | L 2 | PD | L 1 | L 2 | JS |
ROC1-S | 2.5 | 30 (2.38) | 133 (13.87) | 10 (0.14) | 12 (0.16) | Â | 309 (21.67) | 75 (1.11) | 333 (22.62) |
| Â | 3 | 90 (7.95) | 156 (16.88) | 59 (2.14) | 59 (2.14) | 453 (41.60) | 365 (29.91) | 146 (4.75) | 375 (30.00) |
| Â | 3.5 | 134 (11.98) | 164 (18.25) | 184 (13.23) | 188 (13.55) | 479 (44.63) | 442 (40.04) | 262 (16.33) | 438 (39.95) |
| Â | 4 | 167 (16.82) | 164 (18.71) | 262 (28.28) | 267 (29.00) | 475 (44.53) | 449 (42.32) | 373 (33.58) | 438 (42.09) |
| Â | 4.5 | 180 (19.75) | 159 (18.31) | 290 (34.20) | 299 (35.35) | 467 (42.65) | 443 (41.23) | 373 (35.86) | 427 (41.02) |
ROCI-F | 2.5 | 31 (2.38) | 138 (11.99) | 11 (0.16) | 13 (0.17) | Â | 426 (18.78) | 149 (1.31) | 460 (20.16) |
| Â | 3 | 92 (7.16) | 160 (14.43) | 59 (2.03) | 59 (2.03) | 585 (34.69) | 478 (26.15) | 246 (4.79) | 497 (26.30) |
| Â | 3.5 | 137 (10.80) | 166 (15.23) | 185 (12.00) | 189 (12.30) | 594 (36.60) | 530 (33.44) | 386 (14.49) | 536 (33.27) |
| Â | 4 | 168 (14.06) | 165 (15.39) | 264 (23.75) | 272 (24.47) | 575 (36.40) | 477 (34.70) | 514 (27.89) | 455 (34.04) |
| Â | 4.5 | 181 (16.43) | 160 (15.24) | 295 (28.41) | 306 (29.52) | 540 (34.97) | 461 (33.36) | 492 (29.56) | 446 (32.89) |
TSS | 2.5 | 96 (5.38) | 183 (17.06) | 68 (1.62) | 73 (1.78) | Â | 433 (29.71) | 156 (3.49) | 449 (31.46) |
| Â | 3 | 144 (9.91) | 193 (19.18) | 119 (4.10) | 119 (4.10) | 545 (46.70) | 503 (40.85) | 209 (7.03) | 506 (40.30) |
| Â | 3.5 | 174 (13.55) | 193 (19.78) | 232 (14.84) | 234 (15.07) | 546 (47.81) | 526 (45.53) | 294 (18.12) | 531 (45.95) |
| Â | 4 | 195 (18.07) | 180 (19.46) | 306 (31.34) | 313 (31.77) | 545 (48.11) | 530 (47.40) | 382 (33.80) | 530 (47.18) |
| Â | 4.5 | 203 (20.74) | 172 (18.96) | 325 (36.22) | 343 (37.64) | 509 (45.21) | 511 (45.29) | 396 (36.67) | 509 (45.73) |
TFF | 2.5 | 171 (5.75) | 301 (15.48) | 126 (2.00) | 136 (2.31) | Â | 892 (28.59) | 383 (4.41) | 915 (30.44) |
| Â | 3 | 220 (9.66) | 301 (17.02) | 150 (4.15) | 151 (4.16) | 963 (41.52) | 908 (36.98) | 448 (7.52) | 913 (36.47) |
| Â | 3.5 | 260 (13.22) | 302 (17.42) | 263 (14.08) | 267 (14.32) | 875 (40.64) | 818 (38.86) | 556 (16.84) | 831 (39.42) |
| Â | 4 | 277 (15.98) | 297 (17.40) | 350 (26.28) | 363 (26.94) | 762 (40.05) | 751 (39.60) | 633 (28.87) | 777 (39.38) |
| Â | 4.5 | 295 (18.42) | 288 (17.14) | 401 (30.29) | 395 (31.26) | 613 (37.55) | 616 (37.51) | 618 (30.84) | 664 (38.03) |