Genetic interaction motif finding by expectation maximization – a novel statistical model for inferring gene modules from synthetic lethality

Table 3 GO annotation correlations for GIMF Type 1, Type 2 gene pairs, and gene pairs that are directly synthetic lethal (SL).

Gene pairs	GO correlation			FSL	FPC	Number of pairs	Number of genes
	P	F	C
Type 1	0.47	0.20	0.43	0	0.26	42	31
Type 2	0.47	0.15	0.40	0.07	0.14	78	36
SL	0.25	0.05	0.31	--	0.01	3474	1004

P: biological process; F: molecular function C: cellular component. FSL: fraction of pairs that are directly synthetic lethality; FPC: fraction of pairs that are within the same protein complex. The GIMF Type 1 network contains 31 genes and 42 edges while the Type 2 network contains 36 genes and 78 edges.

ISSN: 1471-2105