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Table 1 Preferences of interface hubs to interact with other residues at Imin = 4%1

From: Oligomeric protein structure networks: insights into protein-protein interactions

Res Hi Ala Arg Asn Asp Cys Gln Glu Gly His Ile Leu Lys Met Phe Pro Ser Thr Trp Tyr Val
ALA 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
ARG 2.06 1.56 10.08 5.74 14.32 0.45 4.62 15.15 0.50 3.34 3.90 3.96 2.28 2.34 6.24 2.79 5.40 4.51 2.45 6.63 3.73
ASN 0.92 3.70 4.27 10.67 9.96 0.43 8.11 7.54 2.56 5.97 2.42 4.27 2.13 2.42 4.84 3.70 2.84 6.40 2.42 6.26 9.10
ASP 0.27 1.51 18.87 3.02 4.15 0.00 3.02 5.28 0.00 7.92 0.38 5.66 2.64 1.89 5.28 6.79 7.55 9.43 5.66 9.06 1.89
CYS 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
GLN 0.70 1.35 5.84 8.09 5.62 0.90 12.58 7.64 0.45 2.47 3.82 8.31 1.35 4.04 6.52 1.80 3.82 6.74 3.60 9.66 5.39
GLU 0.53 1.04 20.42 3.11 2.60 1.21 3.46 3.29 0.87 7.44 6.23 4.84 6.06 3.29 7.44 2.60 6.06 7.61 2.60 7.79 2.08
GLY 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
HIS 1.48 1.18 7.24 12.46 7.24 1.52 3.03 5.89 0.84 12.12 4.04 5.72 2.53 4.71 2.69 0.34 5.72 6.90 3.54 5.56 6.73
ILE 0.31 0.33 6.31 1.66 3.32 0.00 8.64 6.31 0.33 3.32 6.64 9.63 3.32 5.32 14.95 2.33 5.65 4.65 4.65 6.64 5.98
LEU 0.33 2.56 11.44 3.75 5.92 0.79 6.51 4.14 1.38 5.72 6.31 8.09 1.78 1.18 7.69 4.54 3.94 2.37 4.34 6.31 11.24
LYS 0.48 2.52 5.03 5.49 13.04 1.14 4.35 17.39 1.14 3.89 3.43 5.49 0.23 3.66 3.20 1.37 8.47 5.72 2.75 9.15 2.52
MET 1.22 4.99 6.07 7.81 5.64 1.95 3.69 3.25 1.30 3.90 5.21 8.46 3.90 7.81 8.68 2.82 5.42 1.74 3.25 7.59 6.51
PHE 1.40 1.23 5.53 3.89 5.53 1.13 4.10 2.97 1.02 3.89 8.09 7.89 2.15 4.61 14.45 2.97 3.48 4.51 3.69 10.86 7.99
PRO 0.11 0.00 5.81 5.81 6.98 1.16 0.00 3.49 0.00 4.65 0.00 4.65 0.00 0.00 10.47 13.95 6.98 3.49 5.81 20.93 5.81
SER 0.06 0.00 9.09 0.00 9.09 0.00 16.36 0.00 0.00 7.27 0.00 0.00 0.00 0.00 10.91 0.00 16.36 23.64 7.27 0.00 0.00
THR 0.05 0.00 0.00 14.00 4.00 0.00 26.00 12.00 0.00 6.00 6.00 0.00 8.00 0.00 12.00 2.00 2.00 6.00 0.00 0.00 2.00
TRP 2.28 1.95 5.07 8.38 4.29 0.39 7.21 3.51 0.97 3.51 7.80 7.21 3.90 2.53 11.31 2.73 2.92 7.02 3.31 11.31 4.68
TYR 1.47 0.56 11.26 6.31 7.77 0.56 5.07 7.21 1.69 4.17 5.07 5.52 5.29 2.48 7.09 6.64 2.93 2.48 3.60 8.45 5.86
VAL 0.03 0.00 5.56 0.00 2.78 0.00 5.56 5.56 0.00 5.56 0.00 11.11 0.00 0.00 36.11 0.00 0.00 0.00 8.33 16.67 2.78
  1. 11: The rows of the table (i) correspond to the twenty different types of amino acids forming the interface hubs. The second element in each row gives Hi, the percentage of amino acids of each type 'i' forming interface hubs in the dataset (with respect to the total number of residues of type 'i' in the dataset). Elements three to twenty two in each row correspond to the percentage of interactions that the amino acid hub of type 'i' makes with the twenty different amino acid types (j) [with respect to the total number of interactions made by hub residue type 'i']. This gives the 20 × 20 matrix for the interactions of the interface hubs with other residues at Imin = 4%. Thus, each ijth element in the 20 × 20 matrix gives the percentage interactions of interface hub type 'i' with residue type 'j'.