Table 3 Comparison of interface clusters and hubs with experimental dissociation constants of oligomeric proteins
From: Oligomeric protein structure networks: insights into protein-protein interactions
Protein [Reference] | PDB Code | Kd1 | No. of interface hubs | Size of the largest interface cluster | Nic (Nires)2 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Imin (%) | Imin (%) | Imin (%) | ||||||
| Â | Â | Â | 0 | 2 | 4 | 4 | 6 | 8 | 4 | 6 | 8 |
E-Cadherin [50] | 1edh | 170 μM | 14 | 3 | 1 | 41 | 3 | 0 | 2(44) | 3(9) | 0 |
β-Lactoglobulin [50] | 1beb | 20 μM | 13 | 3 | 2 | 32 | 4 | 0 | 3(43) | 2(7) | 0 |
Insulin [50] | 1trz | 1 μM | 13 | 8 | 2 | 31 | 6 | 0 | 3(37) | 4(18) | 0 |
Elongation Factor EF-TU/EF-TS Complex [50] | 1efu | 30 nM | 54 | 27 | 11 | 61 | 18 | 11 | 8(190) | 7(63) | 5(28) |
Rac-ExoS GAP domain [50] | 1he1 | 20–30 nM | 24 | 13 | 2 | 94 | 9 | 7 | 4(146) | 4(23) | 2(10) |
CD4-GP120 [51] | 1gc1 | 5 nM | 28 | 13 | 5 | 86 | 15 | 8 | 4(152) | 3(32) | 3(21) |
Ran-Importin-β [50] | 1ibr | 0.6 nM | 49 | 18 | 7 | 131 | 15 | 11 | 6(173) | 5(48) | 4(22) |
Growth hormone-Receptor [52] | 2hhr | 0.15 nM | 46 | 21 | 12 | 257 | 34 | 22 | 6(344) | 7(86) | 5(57) |