Skip to main content

Table 3 Comparison of interface clusters and hubs with experimental dissociation constants of oligomeric proteins

From: Oligomeric protein structure networks: insights into protein-protein interactions

Protein [Reference] PDB Code Kd1 No. of interface hubs Size of the largest interface cluster Nic (Nires)2
    Imin (%) Imin (%) Imin (%)
    0 2 4 4 6 8 4 6 8
E-Cadherin [50] 1edh 170 μM 14 3 1 41 3 0 2(44) 3(9) 0
β-Lactoglobulin [50] 1beb 20 μM 13 3 2 32 4 0 3(43) 2(7) 0
Insulin [50] 1trz 1 μM 13 8 2 31 6 0 3(37) 4(18) 0
Elongation Factor EF-TU/EF-TS Complex [50] 1efu 30 nM 54 27 11 61 18 11 8(190) 7(63) 5(28)
Rac-ExoS GAP domain [50] 1he1 20–30 nM 24 13 2 94 9 7 4(146) 4(23) 2(10)
CD4-GP120 [51] 1gc1 5 nM 28 13 5 86 15 8 4(152) 3(32) 3(21)
Ran-Importin-β [50] 1ibr 0.6 nM 49 18 7 131 15 11 6(173) 5(48) 4(22)
Growth hormone-Receptor [52] 2hhr 0.15 nM 46 21 12 257 34 22 6(344) 7(86) 5(57)
  1. 1: Kd: Experimental dissociation constant
  2. 2: Nic (Nires): No. of interface clusters (No. of residues in the interface clusters)