Figure 2
From: Evolutionary programming as a platform for in silico metabolic engineering
Representation of the metabolic genotype. Each gene of the microorganism is assigned a binary value, representing its absence/presence in the mutant (A). The individual genes are associated with one or more reactions in the metabolic network (B). When a given reaction is in the absent status, the upper and lower bonds for the corresponding metabolic flux are set to zero, resulting in a modified metabolic model (C).