TY - JOUR AU - Ahmad, Shandar AU - Sarai, Akinori PY - 2005 DA - 2005/02/19 TI - PSSM-based prediction of DNA binding sites in proteins JO - BMC Bioinformatics SP - 33 VL - 6 IS - 1 AB - Detection of DNA-binding sites in proteins is of enormous interest for technologies targeting gene regulation and manipulation. We have previously shown that a residue and its sequence neighbor information can be used to predict DNA-binding candidates in a protein sequence. This sequence-based prediction method is applicable even if no sequence homology with a previously known DNA-binding protein is observed. Here we implement a neural network based algorithm to utilize evolutionary information of amino acid sequences in terms of their position specific scoring matrices (PSSMs) for a better prediction of DNA-binding sites. SN - 1471-2105 UR - https://doi.org/10.1186/1471-2105-6-33 DO - 10.1186/1471-2105-6-33 ID - Ahmad2005 ER -