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Table 1 p-values of the original two-part test and the two-part permutation test for seven regions in lung cancer cell lines; DNA methylation data from Siegmund et al. [4]

From: Two-part permutation tests for DNA methylation and microarray data

Region

Original two-part test

Two-part permutation test1

CALCA

p = 0.0005

p = 0.0004

PTGS2

p = 0.0002

p = 0.0001

MTHFR

p = 0.0007

p = 0.0002

MGMT-M1

p = 0.0860

p = 0.0857

APC

p = 0.1684

p = 0.1712

MYOD1

p = 0.0132

p = 0.0111

ESR1

p = 0.0040

p = 0.0030

  1. 1performed based on simple random samples of 20,000 permutations (when using 20,000 permutations a 95%-confidence interval for the p-value is the observed p-value ± 0.007 when p = 0.5, or ± 0.003 when p = 0.05).