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Table 5 significant GO terms for the Lehner dataset A selection of GO terms with significant correlations to the 20 clusters in the Lehner dataset, clustered by removing 57 edges. (The numbers after the descriptions show the proportion of proteins in the cluster which were annotated with that GO term). The complete set of GO terms for each of these clusters can be seen in Additional file 7 and the identity of the transcripts associated with the significant GO terms can be found in Additional file 8.

From: The Use of Edge-Betweenness Clustering to Investigate Biological Function in Protein Interaction Networks

Cluster Number

Size of Cluster

Significant GO descriptions

15

20

ubiquitination 4/20

4

49

protein biosynthesis 7/49, RNA catabolism 4/49, translation 3/49

19

3

ubiquitin 1/3, cell defence 1/3

8

24

electron transport 2/24

11

10

transcription regulation3/10

16

22

transport 6/22, glucose catabolism 2/22

18

7

DNA repair 2/7

3

60

RNA splicing 14/60, spliceosome 5/60

7

10

ribosome assembly 2/10, cytoplasmic exosome 1/10

12

8

protein metabolism 3/8, phosphorylation 3/8

22

1

morphogenesis 1/2, membrane 1/2

2

19

signal transduction 4/19, ER 3/19

9

4

transcription reg 1/4

21

4

mRNA catabolism 1/4

6

12

mRNA export 1/12, DNA binding 4/12

1

18

cytoskeleton 3/18

20

2

ATP biosynthesis 2/2

14

14

DNA replication 2/14, cell cycle 3/14

10

23

biological process 8/23 oncogenesis 2/23