Figure 1
From: Computational verification of protein-protein interactions by orthologous co-expression
Higher correlation of expression profiles among interacting protein-pairs. (a) Cumulative distributions of correlations between expression profiles of protein-pairs from a reference set of 1656 known interactions taken from the MIPS database, and a set of randomly chosen pairs of proteins (averaged over ten trials). The dashed line represents a possible correlation threshold (0.155) that can be used for prediction of PPIs. (b) The predictive power of this approach. Each point in this plot represents a specific correlation threshold for the prediction of PPIs. The vertical axes shows the percentage of interaction identified from the reference set (true positives) and the horizontal axes shows the percentage of interaction identified from the random set (false positives). The dashed lines represent the performance of the threshold shown in (a).