Figure 3

Receiver operating characteristics (ROC) of the 8 selected groups of genes to quantify their coherence upon clustering of literature co-occurrences. Co-occurrences of the 150 genes were determined with the genes themselves, or the 5 different keyword thesauri. A co-occurrence was only taken into account when at least two articles mention the gene-gene or gene-keyword pair. The co-occurrence matrixes were Pearson correlation clustered and the distances between genes determined. For each gene, it was determined whether the next closest clustered gene was a group member. Genes from the same group were scored as true positive and any other gene as false positive to generate a ROC curve. For each gene, the area under the ROC curve (AUC) was determined and the median of all the group members per group ± SD depicted. Scaling is from an AUC of 0.3 to 1. An AUC of 0.5, representing a random ordering is highlighted with a thick line.