Figure 4
From: CoPub Mapper: mining MEDLINE based on search term co-publication
Hierarchical clustering of literature co-occurences of 104 genes (rows) versus 761 biological processes and diseases (columns). A co-occurrence was only taken into account when at least three articles mention the gene-keyword pair. Hierarchical clustering of CoPub Mapper results using genes differentially expressed in PCOS ovaries. From 221 regulated genes 104 genes contain a gene name, symbol or alias and produce a gene-keyword pair with biological processes or diseases. 104 modulated genes returned 761 keywords denoting biological processes or diseases. Hierarchical clustering was performed using Spotfire using the Complete Linkage method and Correlation as Similarity Measure. Several subclusters were identified shown here with blue boxes; between parenthesis the number of genes in a cluster. A: PCOS, Obesity, Insulin Resistance (4); B & D: Gametogenesis (5&8); C: Cell adhesion, Angiogenesis (19); E & H: Immune response, Inflammation (14&11); F: Cancer, Cell growth, Differentiation (32); G: Inflammatory diseases (6).