From: Speeding disease gene discovery by sequence based candidate prioritization
Feature | Source | Description |
---|---|---|
Gene length | EnsemblMart 22.1 | Length of gene in bp. |
CDS length | EnsemblMart 22.1 | Length of coding sequence in bp. |
cDNA length | EnsemblMart 22.1 | Length of complementary DNA in bp. |
Protein length | EnsemblMart 22.1 | Length of protein in aa. |
Length of 3' UTR | EnsemblMart 22.1 | The length of the 3' untranslated region (UTR) in bp |
Length of 5' UTR | EnsemblMart 22.1 | The length of the 5' untranslated region (UTR) in bp |
Distance to nearest neighbouring gene | EnsemblMart 22.1 | Distance to the next known gene on the same chromosome on either strand in bp. |
Number of exons | EnsemblMart 22.1 | Number of exons in the gene. |
GC | EnsemblMart 22.1 | GC content (as a %) of gene |
Transmembrane | EnsemblMart 22.1 | Prediction of transmembrane domains (1 for yes or 0 for no) |
Signal peptide | EnsemblMart 22.1 | Prediction of signal peptide (1 for yes or 0 for no) |
Paralog | EnsemblMart 22.1 | If the gene has a paralog in the human genome (1 for yes or 0 for no) |
Paralog % identity | EnsemblMart 22.1 | % protein identity of best paralog in the human genome. Genes without paralogs have "unknown" entered here. |
Mouse homolog % identity | Homologene | % protein identity of mouse homolog. Genes without a mouse homolog have "0" entered here. |
Rat homolog % identity | Homologene | % protein identity of rat homolog. Genes without a rat homolog have "0" entered here. |
Worm homolog % identity | Homologene | % protein identity of worm homolog (potentially 0, see above) |
Fly homolog % identity | Homologene | % protein identity of fly homolog (potentially 0, see above) |
Yeast homolog % identity | Homologene | % protein identity of yeast homolog (potentially 0, see above) |
Arabidopsis homolog % identity | Homologene | % protein identity of Arabidopsis homolog (potentially 0, see above) |
Mouse homolog Ka | Homologene | Measure of non-synonymous changes between human and mouse homolog. |
Mouse homolog Ks | Homologene | Measure of synonymous changes between human and mouse homolog. |
Mouse homolog Ka / Ks | Homologene | Ratio of above two fields. |
CpG island at 3' end of gene | EnsemblMart 22.1 | If a CpG island exists at the 3' end of the gene (1 or 0) |
CpG island at 5' end of gene | EnsemblMart 22.1 | If a CpG island exists at the 5' end of the gene (1 or 0) |