Figure 3

Random effects meta-analysis of simulated results. (a) A comparison of the fixed effects and random effects meta-analysis estimates of SLR shows general agreement between the models. (b) The histogram of significance P-values shows an abundance of significantly differentially expressed genes, as evidenced by the large number of smaller significance P-values. (c) The smallest significance P-values tended to occur for genes whose random effects meta-analysis SLR estimates were large in absolute value. The reference line is the P-value cut-off used to control the False Discovery Rate at 0.05. Using this cut-off, the random effects meta-analysis declared 72 of the 1322 genes significantly differentially expressed. (d) Demonstration of how the SLR's estimated from the meta-analysis relate to their standard errors.