BMC Bioinformatics

Table 1 Comparison of results from the simulated data. Comparison of numbers of genes in common declared significant (i.e., significantly differentially expressed) by simulated labs 1 through 6, the SLR-based fixed effexts and random effects meta-analyses, and the previously proposed P-value-based meta-analysis [2]. The (i, j)^thelement of this table is the number of genes declared significant by both lab i and lab j, with F here representing the fixed effects meta-analysis, R the random effects meta-analysis, and T the "truth" behind the simulation model. P represents the meta-analysis based on P-values [2]. Each lab (and meta-analysis) had the False Discovery Rate (FDR) controlled at 0.05.

From: Combining Affymetrix microarray results

	Simulated Lab						Meta-Analysis
	1	2	3	4	5	6	Fixed	Random	P-value	Truth
1	46	33	34	34	31	31	43	35	33	35
2		49	34	37	31	34	47	39	35	38
3			54	34	32	36	44	41	38	41
4				51	30	35	48	38	35	39
5					44	32	39	37	34	37
6						58	48	40	37	41
F							137	72	45	58
R								72	45	56
P									45	45
T										70

Back to article page

ISSN: 1471-2105

Contact us

General enquiries: journalsubmissions@springernature.com